Publications

Recent publications:

2023

Petropoulos M, Champeris Tsaniras S, Nikou S, Maxouri S, Dionellis VS, Kalogeropoulou A, Karamichali A, Ioannidis K, Danalatos IR, Obst M, Naumann R, Delinasios GJ, Gorgoulis VG, Roukos V, Anastassiadis K, Halazonetis TD, Bravou V, Lygerou Z, Taraviras S.(2023) Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage. The journal of pathology .doi: 10.1002/path.6017

2022

Angelopoulos I, Gakis G, Birmpas K, Kyrousi C, Habeos EE, Kaplani K, Lygerou Z, Habeos I, Taraviras S. (2022). Metabolic regulation of the neural stem cell fate: Unraveling new connections, establishing new concepts.Frontiers in Neuroscience. doi: 10.3389/fnins.2022.1009125

Nikou S, Arbi M, Dimitrakopoulos FD, Kalogeropoulou A, Geramoutsou C, Zolota V, Kalofonos HP, Taraviras S, Lygerou Z, Bravou V.(2022) Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma.Clinical and experimental medicine. doi: 10.1007/s10238-022-00847-8

Geramoutsou C, Nikou S, Karavias D, Arbi M, Tavlas P, Tzelepi V, Lygerou Z, Maroulis I, Bravou V.(2022).Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel tumour suppressor with prognostic significance. Pathology, research and practice.doi: 10.1016/j.prp.2022.153950

Kalogeropoulou A, Mougkogianni M, Iliadou M, Nikolopoulou E, Flordelis S, Kanellou A, Arbi M, Nikou S, Nieminuszczy J, Niedzwiedz W, Kardamakis D, Bravou V, Lygerou Z, Taraviras S.(2022).Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress. Stem Cell Reports doi: 10.1016/j.stemcr.2022.04.018

Tsaridou S, Velimezi G, Willenbrock F, Chatzifrangkeskou M, Elsayed W, Panagopoulos A, Karamitros D, Gorgoulis V, Lygerou Z, Roukos V, O’Neill E, Pefani DE.(2022) 53BP1-mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling. EMBO reports.doi: 10.15252/embr.202154483

Karantzelis N, Petropoulos M, De Marco V, Egan DA, Fish A, Christodoulou E, Will DW, Lewis JD, Perrakis A, Lygerou Z, Taraviras S.(2022)Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells. Frontiers in pharmacology doi: 10.3389/fphar.2022.860682

Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG.(2022) Author Correction: Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.Genome Biology. doi: 10.1186/s13059-022-02678-y

Badra Fajardo N., Taraviras S., Lygerou Z. (2022). Fanconi anemia proteins and genome fragility: unraveling replication defects for cancer therapy. Trends in Cancer. doi: 10.1016/j.trecan.2022.01.015

Kasselimi, E., Pefani, D. E., Taraviras, S., & Lygerou, Z. (2022). Ribosomal DNA and the nucleolus at the heart of aging. Trends in Biochemical Sciences, S0968-0004(21)00276-0. Advance online publication. https://doi.org/10.1016/j.tibs.2021.12.007

2021

Ioannidis, K., Angelopoulos, I., Gakis, G., Karantzelis, N., Spyroulias, G. A., Lygerou, Z., & Taraviras, S. (2021). 3D Reconstitution of the Neural Stem Cell Niche: Connecting the Dots. Frontiers in Bioengineering and Biotechnology, 9, 705470. https://doi.org/10.3389/fbioe.2021.705470

Loukas, I., Skamnelou, M., Tsaridou, S., Bournaka, S., Grigoriadis, S., Taraviras, S., Lygerou, Z. and Arbi, M. (2021), Fine-tuning multiciliated cell differentiation at the post-transcriptional level: contribution of miR-34/449 family members. Biol Rev. doi.org/10.1111/brv.12755

Mäkelä R., Härmä V., Badra Fajardo N., Wells G., Lygerou Z., Sangfelt O., Kononen J., Rantala J. K. (2021) Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma. Oncotarget. ; 12. Retrieved from https://www.oncotarget.com/article/27961/text/

Rapsomaniki MA, Maxouri S, Nathanailidou P, Garrastacho MR, Giakoumakis NN, Taraviras S, Lygeros J, Lygerou Z (2021) In silico analysis of DNA re-replication across a complete genome reveals cell-to-cell heterogeneity and genome plasticity. NAR Genomics and Bioinformatics 2021 Mar 3(1). doi: 10.1093/nargab/lqaa112

2020

Mougkogianni M, Kalogeropoulou A, Giakoumakis NN, Lygerou Z, Taraviras S. (2020) Ιn vivo imaging of DNA-bound minichromosome maintenance complex in embryonic mouse cortex. STAR Protoc. 2020 Dec 19;2(1):100234. doi: 10.1016/j.xpro.2020.100234. PMID: 33364622; PMCID: PMC7753948.

Ioannidis K, Danalatos RI, Champeris Tsaniras S, Kaplani K, Lokka G, Kanellou A, Papachristou DJ, Bokias G, Lygerou Z, Taraviras S. (2020) A Custom Ultra-Low-Cost 3D Bioprinter Supports Cell Growth and Differentiation. Front Bioeng Biotechnol. 2020 Nov 4;8:580889. doi: 10.3389/fbioe.2020.580889. PMID: 33251196; PMCID: PMC7676439.

Nathanailidou P, Taraviras S, Lygerou Z. (2020) Chromatin and Nuclear Architecture: Shaping DNA Replication in 3D. Trends Genet. 2020 Dec;36(12):967-980. doi: 10.1016/j.tig.2020.07.003. Epub 2020 Jul 23. PMID: 32713597.

Nikou S, Arbi M, Dimitrakopoulos FD, Sirinian C, Chadla P, Pappa I, Ntaliarda G, Stathopoulos GT, Papadaki H, Zolota V, Lygerou Z, Kalofonos HP, Bravou V. (2020) Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival. J Mol Histol. 2020 Aug;51(4):385-400. doi: 10.1007/s10735-020-09888-3. Epub 2020 Jun 22. PMID: 32592097.

Chadla P, Arbi M, Nikou S, Kalliakoudas T, Papadaki H, Taraviras S, Lygerou Z, Bravou V. (2020) Integrin-Linked-Kinase Overexpression Is Implicated in Mechanisms of Genomic Instability in Human Colorectal Cancer. Dig Dis Sci. 2020 Jun 3. doi: 10.1007/s10620-020-06364-6. Epub ahead of print. PMID: 32495257.

Kanellou A, Giakoumakis NN, Panagopoulos A, Tsaniras SC, Lygerou Z. (2020) The Licensing Factor Cdt1 Links Cell Cycle Progression to the DNA Damage Response. Anticancer Res. 2020 May;40(5):2449-2456. doi: 10.21873/anticanres.14214. PMID: 32366388.

Panagopoulos A, Taraviras S, Nishitani H, Lygerou Z. (2020) CRL4Cdt2: Coupling Genome Stability to Ubiquitination. Trends Cell Biol. 2020 Apr;30(4):290-302. doi: 10.1016/j.tcb.2020.01.005. Epub 2020 Feb 7. PMID: 32044173.

2019

Lalioti ME, Kaplani K, Lokka G, Georgomanolis T, Kyrousi C, Dong W, Dunbar A, Parlapani E, Damianidou E, Spassky N, Kahle KT, Papantonis A, Lygerou Z, Taraviras S. (2019) GemC1 is a critical switch for neural stem cell generation in the postnatal brain. Glia. 2019 Dec;67(12):2360-2373. doi: 10.1002/glia.23690. Epub 2019 Jul 22. PMID: 31328313.

Petropoulos M, Champeris Tsaniras S, Taraviras S, Lygerou Z. (2019) Replication Licensing Aberrations, Replication Stress, and Genomic Instability. Trends Biochem Sci. 2019 Sep;44(9):752-764. doi: 10.1016/j.tibs.2019.03.011. Epub 2019 May 1. PMID: 31054805.

Lalioti ME, Arbi M, Loukas I, Kaplani K, Kalogeropoulou A, Lokka G, Kyrousi C, Mizi A, Georgomanolis T, Josipovic N, Gkikas D, Benes V, Politis PK, Papantonis A, Lygerou Z, Taraviras S. (2019) GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73. J Cell Sci. 2019 Jun 3;132(11):jcs228684. doi: 10.1242/jcs.228684. PMID: 31028178.

Kalogeropoulou A, Lygerou Z, Taraviras S. (2019) Cortical Development and Brain Malformations: Insights From the Differential Regulation of Early Events of DNA Replication. Front Cell Dev Biol. 2019 Mar 11;7:29. doi: 10.3389/fcell.2019.00029. PMID: 30915332; PMCID: PMC6421272.

2018

Hayashi A, Giakoumakis NN, Heidebrecht T, Ishii T, Panagopoulos A, Caillat C, Takahara M, Hibbert RG, Suenaga N, Stadnik-Spiewak M, Takahashi T, Shiomi Y, Taraviras S, von Castelmur E, Lygerou Z, Perrakis A, Nishitani H. (2018) Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1. Life Sci Alliance. 2018 Dec 31;1(6):e201800238. doi: 10.26508/lsa.201800238. PMID: 30623174; PMCID: PMC6312923.

Maxouri S, Taraviras S, Lygerou Z. (2018) Visualizing the dynamics of histone variants in the S-phase nucleus. Genome Biol. 2018 Oct 31;19(1):182. doi: 10.1186/s13059-018-1556-4. PMID: 30382897; PMCID: PMC6211500.

Champeris Tsaniras S, Villiou M, Giannou AD, Nikou S, Petropoulos M, Pateras IS, Tserou P, Karousi F, Lalioti ME, Gorgoulis VG, Patmanidi AL, Stathopoulos GT, Bravou V, Lygerou Z, Taraviras S. (2018) Geminin ablation in vivo enhances tumorigenesis through increased genomic instability. J Pathol. 2018 Jun 27. doi: 10.1002/path.5128. [Epub ahead of print]

Grigorios Koulouras, Andreas Panagopoulos, Maria A Rapsomaniki, Nickolaos N Giakoumakis, Stavros Taraviras, Zoi Lygerou (2018) EasyFRAP-web: a web-based tool for the analysis of fluorescence recovery after photobleaching data. Nucleic Acids Research. 2018 June 13. doi: 10.1093/nar/gky508

Tsiaoussis GI, Papaioannou EC, Kourea EP, Assimakopoulos SF, Theocharis GI, Petropoulos M, Theopistos VI, Diamantopoulou GG, Lygerou Z, Spiliopoulou I, Thomopoulos KC. (2018) Expression of α-Defensins, CD20+ B-lymphocytes, and Intraepithelial CD3+ T-lymphocytes in the Intestinal Mucosa of Patients with Liver Cirrhosis: Emerging Mediators of Intestinal Barrier Function. Dig Dis Sci. 2018 Jun 7. doi: 10.1007/s10620-018-5146-9. [Epub ahead of print]

Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG. (2018) Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9.

2017

Arbi M, Pefani DE, Taraviras S, Lygerou Z (2017). Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis. Chromosoma. 2017 Dec 14. doi: 10.1007/s00412-017-0652-7

Panagopoulos A, Taraviras S, Lygerou Z (2017). Mismatch Repair regulates Cdt1 after UV damage. Cell Cycle. 2017 Apr 20:0. doi: 10.1080/15384101.2017.1319687.

Giakoumakis NN, Rapsomaniki MA, Lygerou Z (2017).Analysis of Protein Kinetics Using Fluorescence Recovery After Photobleaching(FRAP).Methods Mol Biol. 2017;1563:243-267. doi: 10.1007/978-1-4939-6810-7_16.

Kyrousi C,Lygerou Z, Taraviras S.(2017)How a radial glial cell decides to become a multiciliated ependymal cell. Glia.2017 Jul;65(7):1032-1042. doi: 10.1002/glia.23118.

Patmanidi AL, Champeris Tsaniras S, Karamitros D, Kyrousi C,Lygerou Z , Taraviras S. (2017) Concise Review: Geminin-A Tale of Two Tails: DNA Replication and Transcriptional/Epigenetic Regulation in Stem Cells. Stem Cells. 2017 Feb;35(2):299-310. doi: 10.1002/stem.2529.

2016

Kyrousi C, Lalioti ME, Skavatsou E, Lygerou Z, Taraviras S.(2016)Mcidas and GemC1/Lynkeas specify embryonic radial glial cells. Neurogenesis (Austin). 2016, 3(1):e1172747.

Patmanidi AL, Kanellakis NI, Karamitros D, Papadimitriou C, Lygerou Z, Taraviras S.(2016) Whole transcriptome data analysis of mouse embryonic hematopoietic stem and progenitor cells that lack Geminin expression. Data Brief. 2016 Mar 12;7:889-93.

K. Vakaloglou, G. Chrysanthis, M-A Rapsomaniki, Z. Lygerou, C. Zervas (2016) IPP Complex Reinforces Adhesion by Relaying Tension-Dependent Signals to Inhibit Integrin Turnover. Cell Reports 2016, 17:2268-2282.

M. Arbi, D-E Pefani, C. Kyrousi, M-E Lalioti, A. D. Papanastasiou, S.Taraviras and Z. Lygerou.(2016) GemC1 controls multiciliogenesis in the airway epithelium” EMBO Reports 2016, Mar; 17(3):400-13.

Stathopoulou A, Natarajan D, Nikolopoulou P, Patmanidi AL, Lygerou Z, Pachnis V, Taraviras S.(2016) Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis. Developmental Biology 2016, Jan 15;409(2):392-405.

2015

Caillat C, Fisha A, Pefani E-D, Taraviras S , Lygerou Z and Perrakis A. (2015) The crystal structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins. Acta Crystallographica D. 2015, Nov 1;71(Pt 11):2278-86

Kyrousi C, Arbi M, Pilz GA, Pefani DE, Lalioti ME, Ninkovic J, Götz M, Lygerou Z, Taraviras S.(2015) Mcidas and GemC1/Lynkeas are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche. Development 2015, 142(21):3661-74

Kourti M, Ikonomou G, Giakoumakis NN, Rapsomaniki MA, Landegren U, Siniossoglou S, Lygerou Z, Simos G, Mylonis I.(2015) CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation. Cell Signal. 2015 Jun;27(6):1129-40.

Rapsomaniki, M. A., Cinquemani, E., Giakoumakis, N. N., Kotsantis, P., Lygeros, J., & Lygerou Z. (2015). Inference of protein kinetics by stochastic modeling and simulation of fluorescence recovery after photobleaching experiments. Bioinformatics, 2015 Feb 1;31(3):355-62.

Karamitros D, Patmanidi AL, Kotantaki P, Potocnik AJ, Bähr-Ivacevic T, Benes V, Lygerou Z, Kioussis D, Taraviras S. (2015). Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors. Development, 2015 Jan 1;142(1):70-81.

2014

Champeris Tsaniras S, Kanellakis N, Symeonidou IE, Nikolopoulou P, Lygerou Z, Taraviras S. (2014) Licensing of DNA replication, cancer, pluripotency and differentiation: An interlinked world? Semin Cell Dev Biol. , 2014 Jun;30:174-80

2013

Symeonidou IE, Kotsantis P, Roukos V, Rapsomaniki MA, Grecco HE, Bastiaens P, Taraviras S, Lygerou Z. (2013) Multi-step loading of human Mini-Chromosome Maintenance Proteins in live human cells.  J Biol. Chem.  288(50): 35852-67

Caillat C, Pefani ED, Gillespie PJ, Taraviras S, Blow JJ, Lygerou Z, Perrakis A. (2013) The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing. J Biol. Chem.  288(44):31624-34

Dimaki M.,  Xouri G.,  Symeonidou I.E., Sirinian H., Nishitani H., Taraviras S. and Lygerou Z. (2013) Cell-cycle dependent subcellular translocation of human Geminin.  J Biol. Chem.  288(33):23953-63

Iliou M, Kotantaki P, Karamitros D, Spella M, Taraviras S and Lygerou Z. (2013) Reduced Geminin levels promote cellular senescence. Mech Ageing Dev. 134:10-23

2012

Symeonidou IE, Taraviras S, Lygerou Z. (2012) Control over DNA replication in time and space. FEBS Letters. 586(18):2803-12

Rapsomaniki MA, Kotsantis P, Symeonidou IE, Giakoumakis NN, Taraviras S and Lygerou Z (2012) easyFRAP: an interactive, easy-to-use tool for qualitative and quantitative analysis of Fluorescence Recovery After Photobleaching data. Bioinformatics. 28(13):1800-1

Stathopoulou A, Roukos V, Petropoulou C, Kotsantis P, Karantzelis N, Nishitani H, Lygerou Z, Taraviras S. (2012) Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs. PLoS ONE. 7(3):e34621

Zoi Lygerou, K. K. Koutroumpas and John Lygeros (2012) DNA Replication. Encyclopedia of Systems Biology, in press

2011

Karamitros D, Kotantaki P, Lygerou Z, Kioussis D, Taraviras S. (2011) T cell proliferation and homeostasis: an emerging role for the cell cycle inhibitor geminin. Crit Rev Immunol.,  31(3):209-31.

Spella M, Kyrousi C, Kritikou E, Stathopoulou A, Guillemot F, Koussis D, Pachnis, Lygerou Z, Taraviras S (2011) Geminin regulates cortical progenitor proliferation and differentiation. Stem Cells, 29:1269-1282

Pefani DE, Dimaki M, Spella M, Karantzelis N, Mitsiki E, Kyrousi C, Symeonidou IE, Perrakis A, Taraviras S, Lygerou Z. (2011) Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression. J. Biol. Chem. 286:23234-46

Roukos V, Kinkhabwala A, Colombelli J, Kotsantis P, Taraviras S, Nishitani H, Stelzer E, Bastiaens P, and Lygerou Z. (2011) Dynamic Recruitment of the Licensing Factor Cdt1 to Sites of DNA Damage J. Cell Science. 124:422-432

2010

Karamitros D, Kotantaki P, Lygerou Z, Veiga-Fernandes H, Pachnis V, Kioussis D, Taraviras S (2010) Life without geminin. Cell Cycle. 9(16):3181-5.

Karamitros D, Kotantaki P, Lygerou Z, Veiga-Fernandes H, Pachnis V, Kioussis D, Taraviras S. (2010) Differential Geminin Requirement for Proliferation of Thymocytes and Mature T Cells. J Immunol. 184(5):2432-41

2009

De Marco V, Gillespie PJ, Li A, Karantzelis N, Christodoulou E, Klompmaker R, van Gerwen S, Fish A, Petoukhov MV, Iliou MS, Lygerou Z, Medema RH, Blow JJ, Svergun DI, Taraviras S, Perrakis A. (2009) Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing. Proc Natl Acad Sci USA. 106(47):19807-12

2008

J. Lygeros, K. Koutroumpas, S. Dimopoulos, I. Legouras, P. Kouretas, C. Heichinger, P. Nurse, Z. Lygerou (2008) Stochastic hybrid modelling of DNA replication across a complete genome. Proc Natl Acad Sci USA. 105:12295-12300.

E.Cinquemani, V.Roukos, Z.Lygerou, J.Lygeros (2008) Numerical analysis of FRAP experiments for DNA replication and repair. Proceedings of the 47th IEEE Conference on Decision and Control. Cancun, Mexico, December 2008 (peer reviewed conference paper).

K. Koutroumpas, Z. Lygerou, J. Lygeros (2008) Parameter Identification for a DNA Replication Model. Proceedings of the IEEE International Conference on BioInformatics and BioEngineering, Athens, October 2008 (peer reviewed conference paper)

2007

Liontos M, Koutsami M, Sideridou M, Evangelou K, Kletsas D, Levy B, Kotsinas A, Nahum O, Zoumpourlis V, Kouloukoussa M, Lygerou Z, Taraviras S, Kittas C, Bartkova J, Papavassiliou AG, Bartek J, Halazonetis TD, Gorgoulis VG. (2007) Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res. 67:10899-909.

Xouri G, Dimaki M, Bastiaens PI, Lygerou Z. (2007) Cdt1 interactions in the licensing process: a model for dynamic spatiotemporal control of licensing. Cell Cycle. 6:1549-1552.

Spella M, Britz O, Kotantaki P, Lygerou Z, Nishitani H, Ramsay RG, Flordellis C, Guillemot F, Mantamadiotis T, Taraviras S. (2007) Licensing regulators Geminin and Cdt1 identify progenitor cells of the mouse CNS in a specific phase of the cell cycle. Neuroscience. 147:373-387.

G. Xouri, A. Squire, M. Dimaki, B. Geverts, P. J. Verveer, S. Taraviras, H. Nishitani, A. B. Houtsmuller, P. I. H. Bastiaens, Z.  Lygerou.(2007) Dynamic chromatin association of Cdt1 throughout G1 leads to Geminin recruitment onto chromatin. EMBO J, 26:1303-1314.

V. Roukos, M. S. Iliou, H. Nishitani, M. Gentzel, M. Wilm, S. Taraviras, Z. Lygerou (2007) Geminin cleavage during apoptosis by caspase-3 alters its binding ability to the SWI/SNF subunit Brahma. J. Biol. Chem, 282:9346-9357

2006

P. Kouretas, K. Koutroumpas, J. Lygeros, and Z. Lygerou (2006) Stochastic Hybrid Modelling of Biochemical processes. In Automation and Control Engineering Series, vol. 24, no. 9083, Stochastic Hybrid Systems, Cassandras and Lygeros eds., CRC Press (book chapter)

Legouras, G. Xouri, S. Dimopoulos, J. Lygeros, Z. Lygerou (2006) DNA replication in the fission yeast: Robustness in the face of uncertainty. Yeast, 23 (13): 951-962 (review)

Nishitani H, Sugimoto N, Roukos V, Nakanishi Y, Saijo M, Obuse C, Tsurimoto T, Nakayama KI, Nakayama K, Fujita M, Lygerou Z, Nishimoto T. (2006). Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J. 25(5):1126-36

2004

Karakaidos, P., S. Taraviras, L. Vassiliou, P. Zacharatos, N. Kastrinakis, D. Kougiou, M. Kouloukoussa, H. Nishitani, A. Papavasileiou, Z. Lygerou and V. Gorgoulis (2004). Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of Non-Small-Cell Lung Carcinomas: Synergistic effect with mutant p53 on tumor growth and chromosomal instability-evidence of E2F-1 transcriptional control over hCdt1. American Journal of Pathology, 165 (4): 1351-1365

Nishitani, H., Lygerou, Z., Nishimoto, T. (2004). Proteolysis of DNA replication Licensing Factor Cdt1 in S-phase is performed independently of Geminin through its N-terminal region. J. Biol. Chem. 279:30807-30816

Xouri G, Lygerou Z c, Nishitani H, Pachnis V, Nurse P., Taraviras S.  (2004) Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines. Eur. J. Biochem. – The FEBS Journal  271(16):3368-78

Nishitani H.,  Lygerou, Z. (2004). DNA replication licensing. Frontiers in Bioscience, 9:2115-2132 (review)

2002

Nishitani H., Lygerou, Z. (2002) Control of DNA replication licensing in a cell cycle. Genes to Cells 7, 523-534  (review)

2001

Nishitani, H., Taraviras, S., Lygerou, Z. and Nishimoto, T. (2001). The human homologue of Cdt1, a nuclear protein essential for replication licensing, accumulates in G1 and is destabilized after initiation of S phase in HeLa cells. J. Biol. Chem. 276:44905-44911

Yanow, S., Lygerou, Z and P. Nurse (2001) Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication. EMBO J. 20: 4648-4656

2000

Lygerou, Z and P. Nurse (2000) License withheld: blocking DNA replication onset by Geminin. Science, 290: 2271-2273 (Perspective)

Nishitani, H., Lygerou, Z., Nishimoto, T. and P. Nurse (2000) The Cdt1 protein is required to license DNA for replication in fission yeast Nature, 404:625-628 

Lygerou, Z  and P. Nurse (2000) “Controlling S-Phase in fission yeast” Cold Spring Harbor Symposia on Quantitative Biology. vol LXV:323-331 (review)

1999

Lygerou, Z. and P. Nurse (1999). The fission yeast origin recognition complex is constitutively associated with chromatin and is differentially modified through the cell cycle. J. Cell Sci, 112:3703-3712

Lygerou, Z., G. Christophides and B. Séraphin. (1999). A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing. Mol Cell Biol, 19:2008-2020

1996

Lygerou, Z., H. Pluk., W.J. van Venrooij and B. Séraphin (1996). hPop1: an autoantigenic protein subunit shared by the human RNase P and RNase MRP ribonucleoproteins. EMBO J., 15:5936-5948

Lygerou, Z., C. Allmang, D. Tollervey and B. Séraphin (1996).Accurate processing of a eukaryotic precursor ribosomal RNA by ribonuclease MRP in vitro. Science, 272: 268-270

1994

Lygerou, Z., C. Conesa, P. Lesage, R. Swanson, A. Ruet, M. Carlson, A. Sentenac and B.Séraphin (1994). The yeast BDF1 gene encodes a transcription factor involved in the expression of a broad  class of genes including snRNAs. Nucleic Acids Res. 22:5332-5340.

Lygerou, Z., P. Mitchell, E. Petfalski, B. Séraphin and D. Tollervey. (1994). The POP1 gene encodes a protein component common to the RNase MRP and RNase P ribonucleoproteins.  Genes & Development 8:1423-1433.

1993

Lygerou, Z., S. Kandels-Lewis, B. Séraphin. (1993). Le role des snRNP dans l’épissage des ARN pré-messagers. Médecine/Sciences 9:165-170. (review)